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GI and GA are ineffective in mitochondrial respiration-deficient CML ρ0 cells. (A–C) GI and GA significantly decrease the basal respiration, ATP coupler response and ETC accelerator response in K562 and LAMA84 cells. (D) The pro-apoptotic effects of GI and GA are significantly abolished in mitochondrial respiration-deficient LAMA84 ρ0 cells. All experiments were conducted in independent triplicates. * indicates p < 0.05 and ** indicates p < 0.01.
