Table 2.
Effect of overactive pro-inflammatory cytokine and IKs inhibition on QTc interval measured in guinea pigs.
| Conditions | QTc (ms) (Basal) |
QTc (ms) (Post-Intervention) |
p Value |
ΔQTc (ms) |
n |
|---|---|---|---|---|---|
| Vehicle | 297.3 ± 2.54 | 302.7 ± 3.94 | 0.298 | 5.42 ± 1.45 | 4 |
| IL-6-sIL-6R | 289.3 ± 0.72 | 310.9 ± 4.22 * | 0.003 | 21.66 ± 6.12 | 5 |
| hyperIL-6 (hIL-6) | 299.7 ± 2.61 | 333.9 ± 8.63 * | 0.004 | 34.8 ± 8.15 | 8 |
| hIL-6 + Olamkicept | 292.9 ± 5.47 | 293.8 ± 4.24 | 0.899 | 0.93 ± 8.30 | 3 |
| Coumermycin | 299.1 ± 5.40 | 337.5 ± 10.7 * | 0.01 | 38.4 ± 10.9 | 7 |
| IL-6-sIL-6R + IL-18 | 292.3 ± 10.7 | 319.2 ± 10.7 * | 0.0004 | 26.95 ± 3.98 | 6 |
| Chromanol293B | 308.6 ± 4.24 | 327.9 ± 5.68 * | 0.018 | 19.23 ± 3.35 | 8 |
| Chromanol293B + ISO- 10 min | 308.6 ± 4.24 | 342.5 ± 7.69 * | 0.004 | 33.0 ± 10.4 | 6 |
| Chromanol293B + ISO + Cytomix- 10 min | 308.6 ± 4.24 | 363.6 ± 6.48 * | 0.0036 | 54.2 ± 11.02 | 3 |
| Chromanol293B + ISO + Cytomix- 30 min | 308.6 ± 4.24 | 377.8 ± 15.3 * | 0.03 | 68.4 ± 17.8 | 3 |
Data are means ± S.E.M. * p < 0.05 compared to corresponding basal controls, two-tailed paired Student’s t test.