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Intranasal application of RBD-yolk preparation in a prophylactic, therapeutic or post-exposure experimental setup in Syrian hamsters. (A) Experimental setup. (B) Relative body weight. (C) Virus genome (genome copies per mL) in nasal washing samples and (D) 5 dpc organ samples. (E) Infectious virus quantified in conchae, lung (cranial) and nasal washing samples of 3 dpc. Statistical differences were calculated by two-way ANOVA with Tukey´s multiple comparison test.
