Table 7.

Recent clinical studies that evaluated CTCs as potential biomarkers in GBM. A search was conducted on Clinicaltrials.gov using the terms “circulating tumor cells”, “CTCs”, and “Glioblastoma” on 6 March 2024.

Rank	NCT Number	Title	Status	Study Results	Conditions	Interventions	Phases	Study Type	URL
1	NCT03861598	Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells	Terminated	No Results Available	Glioblastoma Multiforme, Glioblastoma	Drug: Carvedilol	Early Phase 1	Interventional	https://ClinicalTrials.gov/show/NCT03861598
2	NCT03980249	Anti-Cancer Effects of Carvedilol with Standard Treatment in Glioblastoma and Response of Peripheral Glioma Circulating Tumor Cells	Withdrawn	No Results Available	Glioblastoma, Glioblastoma Multiforme	Drug: Carvedilol	Early Phase 1	Interventional	https://ClinicalTrials.gov/show/NCT03980249
3	NCT01135875	Laboratory Study of Early Tumor Markers in the Peripheral Blood of Glioblastoma Multiforme Patients	Completed	No Results Available	Glioblastoma Multiforme, Healthy Volunteers	Other: GBM Patients, Other: Normal Controls		Observational	https://ClinicalTrials.gov/show/NCT01135875
4	NCT00001148	Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor	Completed	No Results Available	Astrocytoma, Glioblastoma, Glioma			Observational	https://ClinicalTrials.gov/show/NCT00001148
5	NCT03115138	Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas.	Terminated	No Results Available	Glioblastoma, Molecular Disease	Other: Correlation between molecular anomalies of the primary tumor and circulating tumor DNA	Not Applicable	Interventional	https://ClinicalTrials.gov/show/NCT03115138
6	NCT04776980	Multimodality MRI and Liquid Biopsy in GBM	Withdrawn	No Results Available	Glioblastoma Multiforme, Brain Tumor, Adult: Glioblastoma, Brain Tumor, Recurrent, Brain Tumor, Primary	Diagnostic Test: Post-Feraheme Infusion MRI	Early Phase 1	Interventional	https://ClinicalTrials.gov/show/NCT04776980
7	NCT05695976	GRETeL: Tumor Response to Standard Radiotherapy and TMZ Patients With GBM	Recruiting	No Results Available	Glioblastoma, Glioma, Malignant			Observational	https://ClinicalTrials.gov/show/NCT05695976
8	NCT02669173	Capecitabine + Bevacizumab in Patients with Recurrent Glioblastoma	Active, not recruiting	No Results Available	Glioblastoma	Drug: Capecitabine, Drug: Bevacizumab	Phase 1	Interventional	https://ClinicalTrials.gov/show/NCT02669173
9	NCT00905060	HSPPC-96 Vaccine with Temozolomide in Patients with Newly Diagnosed GBM	Completed	Has Results	Brain and Central Nervous System Tumors	Biological: HSPPC-96, Drug: Temozolomide, Procedure: Standard Surgical Resection	Phase 2	Interventional	https://ClinicalTrials.gov/show/NCT00905060
10	NCT00621686	Bevacizumab and Sorafenib in Treating Patients with Recurrent Glioblastoma Multiforme	Completed	Has Results	Brain and Central Nervous System Tumors	Biological: Bevacizumab, Drug: sorafenib tosylate	Phase 2	Interventional	https://ClinicalTrials.gov/show/NCT00621686