Table 7.
Kinetic parameters of drug release from P+DCH and PB1+DCH microparticles.
| P+DCH | PB1+DCH | |||
|---|---|---|---|---|
| pH = 1.2 | pH = 7.4 | pH = 1.2 | pH = 7.4 | |
| Higuchi Model | ||||
| KH (min−0.5) a | 4.482 | 4.360 | 3.848 | 3.895 |
| R2 b | 0.992 | 0.986 | 0.998 | 0.995 |
| Korsmeyer-Peppas Model | ||||
| Kr (min−0.5) c | 0.069 | 0.081 | 0.041 | 0.048 |
| n d | 0.426 | 0.410 | 0.496 | 0.476 |
| R2 b | 0.997 | 0.985 | 0993 | 0.994 |
| Baker-Lonsdale Model | ||||
| KBL (h−0.5) e | 0.028 | 0.031 | 0.020 | 0.023 |
| R2 b | 0.998 | 0.997 | 0.997 | 0.999 |
| Kopcha Model | ||||
| A f | 6.103 | 6.869 | 6.452 | 7.275 |
| B g | −0.115 | −0.143 | −0.021 | −0.052 |
| A/B | 53.070 | 48.035 | 307.238 | 139.904 |
| R2 b | 0.999 | 0.999 | 0.995 | 0.998 |
a KH—the Higuchi dissociation constant; b R2—correlation coefficient; c Kr—the Korsmeyer–Peppas release rate constant; d n—the diffusion exponent corresponding to the release mechanism; e KBL—the Baker–Lonsdale release constant; f A—the diffusion constant; g B—the erosion constant.