Causes of Pre-operative Malnutrition |
Acute and chronic diseases, impaired neurophysiological status, physical inactivity, anxiety, depression, sarcopenia, and decreased appetite due to heart failure and aging. |
Impact on Post-operative Outcomes |
Higher morbidity and mortality, decreased quality of life, and increased risks of complications such as cardiac cachexia and sarcopenia. |
Pathophysiological Mechanisms |
Includes hormonal changes (e.g., cortisol, testosterone), inflammatory cytokines (e.g., TNF-alpha, IL-6), hypoalbuminemia, and altered cardiovascular and metabolic functions. |
Psychosocial Factors |
Psychological stress, neuropsychological issues (e.g., depression, dementia), and lifestyle factors contribute to worsened nutritional status. |