Table 3.

Collagen-based hydrogels in neural regeneration.

Hydrogel Structure	Hydrogel Physical, Chemical, and Biological Characteristics	Neural Disease/Disorder Targeted	Ref
Chitosan/collagen hydrogel hybrid nerve guidance conduit containing Schwann cells	Mechanical strength, bioabsorbable, biocompatible; supports axonal extension	Peripheral nerve regeneration	[11]
Chitosan/collagen hydrogel nerve conduit encapsulating Schwann cells	Synergistic effect on axonal regrowth and remyelination, biocompatibility, mechanical support	Peripheral nerve regeneration	[12]
Collagen type I hydrogel containing chitosan nanoparticles loaded with insulin	Increases Schwann cell proliferation and muscle action potential, promotes nerve regeneration	Peripheral nerve regeneration	[25]
Collagen type I hydrogel containing naringin	Promotes Schwann cell proliferation, porous structure, swelling behavior, cyto/hemocompatibility, biodegradability	Peripheral nerve regeneration	[30]
Hydroxyapatite nanoparticle-containing collagen type I hydrogel	Enhances Schwann cell proliferation, biocompatibility	Peripheral nerve regeneration	[33]
Nanofiber neural guidance channels with collagen hydrogel and acetyl L-carnitine (ALC)	Supports cell attachment and tensile strength, has favorable effects on metabolic activity	Peripheral nerve injury	[56]
Porous PLCL membrane with 3D-printed collagen hydrogel	Elasticity, aligned collagen fibers, longitudinal orientation, nanoporous structure; promotes axonal regeneration and remyelination	Peripheral nerve regeneration	[57]