Table 2.
Clinical characteristics of patients with IFD.
| Patient | Age (years) | Sex | Underlying Neoplasia | Treatment Protocol | IFD | Diagnostic Tools | Prophylaxis | Treatment | IFD Outcome |
|---|---|---|---|---|---|---|---|---|---|
| #1 Ep1 | 17 | M | AML M1 | AML–BFM 2019 |
C. parapsilosis & C. paratropicalis cellulitis |
Biopsy + Culture | LAMB | LAMB–PCZ | Cured |
| #1 Ep2 | 17.5 | IPA | HRCT + Clinical | LAMB | LAMB–VCZ | Cured | |||
| #1 Ep3 | 19 | FLA–IDA | PJP | 3X BAL–PCR + BDG | Pentamidine | SXT → PQ | Cured | ||
| #2 Ep1 | 12.5 | M | AML M5 | AML–BFM 2012 | C. parapsilosis fungemia | Blood culture | MICA | LAMB–VCZ | Cured |
| #2 Ep2 | IPA | HRCT + Clinical | MICA | LAMB–VCZ | Deceased | ||||
| #3 | 3 | M | LCA MB | COG–ACNS0334 | C. parapsilosis fungemia | Blood culture | MICA | LAMB | Relapsed |
| #3 Rel | Blood culture | FCZ | Cured | ||||||
| #4 | 6 | F | AML M5 | AML–BFM 2012 | IPA | HRCT + Clinical | MICA | VCZ–LAMB → CAS | Cured |
| #5 | 2 | F | EPN | VEC | C. albicans fungemia | Blood culture | No | LAMB → MICA | Cured |
| #6 | 0.6 | M | AML M7 | AML–BFM 2019 | C. parapsilosis fungemia | Blood culture | MICA | LAMB–VCZ | Cured |
| #7 | 8 | F | AML M1 | AML–BFM 2019 | IPA | HRCT + Clinical | FCZ | LAMB–VCZ | Cured |
| #8 | 16 | F | AML M5 | AML–BFM 2019 | IPA | HRCT + Clinical | CAS | LAMB–CAS | Deceased |
| #9 | 6 | M | B–ALL | ALL IC–BFM 2009 | IPA | HRCT + Clinical | LAMB | LAMB–VCZ → CAS | Cured |
| #10 | 12 | F | HL | OΕΡA–COPDAC → IEP | IPA | HRCT + Clinical | No | LAMB–VCZ → CAS | Cured |
| #11 | 17 | M | AML M3 | AML–BFM 2019 HR + ATRA | IPA | BAL–PCR + Culture | MICA | ISZ | Cured |
| #12 | 4.5 | M | EWS | EURO EWING 2012 | Exophiala dermatitidis fungemia | Blood culture | VCZ | VCZ | Cured |
ATRA = all-trans retinoic acid; BAL = bronchoalveolar lavage; BDG = (1–3)-β-D-Glucan; CAS = caspofungin; COPDAC = cyclophosphamide, vincristine, prednisolone, dacarbazine; EPN = ependymoma; F = Female; FCZ = fluconazole; FLA–IDA = fludarabine, cytarabine, idarubicin; IEP = ifosfamide, etoposide, prednisolone; ISZ = isavuconazole; LAMB = liposomal amphotericin B; LCA MB = Anaplastic/Large cell medulloblastoma; M = male; MICA = micafungin; OEPA = vincristine, etoposide, prednisolone, doxorubicin; PCR = polymerase chain reaction; PCZ = posaconazole; PQ = primaquine; SXT = trimethoprim/sulfamethoxazole; VCZ = voriconazole; VEC = vincristine, etoposide, cyclophosphamide.