Table 2.
KEGG pathway analysis of differentially expressed proteins in duck lung tissues infected with the HPAI H5N1 virus.
| Pathway | Hits | FDR |
|---|---|---|
| Focal adhesion | 179 | 3.20 × 10−21 |
| PI3K-Akt signaling pathway | 291 | 1.10 × 10−20 |
| MAPK signaling pathway | 243 | 1.12 × 10−17 |
| Cell cycle | 116 | 1.97 × 10−17 |
| Endocytosis | 204 | 2.00 × 10−16 |
| AMPK signaling pathway | 110 | 5.46 × 10−15 |
| Regulation of the actin cytoskeleton | 179 | 1.36 × 10−14 |
| Phospholipase D signaling pathway | 130 | 3.91 × 10−14 |
| T cell receptor signaling pathway | 94 | 4.54 × 10−14 |
| Chemokine signaling pathway | 159 | 3.77 × 10−13 |
| Apoptosis | 119 | 8.99 × 10−13 |
| Spliceosome | 117 | 1.91 × 10−12 |
| Platelet activation | 109 | 4.49 × 10−12 |
| Ubiquitin-mediated proteolysis | 117 | 4.00 × 10−11 |
| mTOR signaling pathway | 128 | 8.53 × 10−11 |
| Fc epsilon RI signaling pathway | 64 | 1.68 × 10−10 |
| Influenza A | 137 | 2.43 × 10−10 |
| Jak-STAT signaling pathway | 132 | 1.20 × 10−9 |
| Protein processing in the endoplasmic reticulum | 134 | 1.32 × 10−9 |
| Proteasome | 44 | 4.35 × 10−9 |
| Toll-like receptor signaling pathway | 88 | 2.57 × 10−8 |
| RIG-I-like receptor signaling pathway | 62 | 1.09 × 10−7 |
| Metabolic pathways | 926 | 1.26 × 10−7 |
| TNF signaling pathway | 91 | 1.26 × 10−7 |
| Th1 and Th2 cell differentiation | 77 | 4.78 × 10−7 |
| Leukocyte transendothelial migration | 91 | 5.95 × 10−7 |