| Factor | Relative risk |
| Involved margins | × 3-4 |
| Extensive in situ component | × 3 |
| Patient's age <35 (v age >50) | × 3 |
| Lymphatic or vascular invasion | × 2 |
| Histological grade II or III (v grade I) | × 1.5 |
| Factor | Relative risk |
| Involved margins | × 3-4 |
| Extensive in situ component | × 3 |
| Patient's age <35 (v age >50) | × 3 |
| Lymphatic or vascular invasion | × 2 |
| Histological grade II or III (v grade I) | × 1.5 |