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. 2024 Jul 18;60(7):1160. doi: 10.3390/medicina60071160

Figure 6.

Figure 6

FASN and SKP2 are upregulated in human hepatocellular carcinoma (HCC). (A) Quantitative real-time RT-PCR values of FASN (first panel) and SKP2 (second panel) are significantly higher in the tumors (HCC) (n = 46) than in corresponding non-tumorous counterparts (ST). (B) Quantitative real-time RT-PCR values of FASN (first panel) and SKP2 (second panel) are significantly higher in HCC with poorer prognosis/shorter survival (HCCP; n = 25) than in tumors with better prognosis/longer survival (HCCB; n = 21). HCCP and HCCB are characterized by <3 and ≥3 years’ survival following partial liver resection. Student’s t-test: ***, p < 0.0001; **, p < 0.005. (C) Evaluation of the relation between FASN and SKP2 mRNA in HCC samples. p values and correlation r values were calculated using Pearson correlation analysis. (D,E) Kaplan–Meyer curves in HCC patients show that FASN (D) and SKP2 (E) mRNA levels inversely correlate with patients’ survival in this disease.