TABLE 3.
Order of accumulation of the point mutations MA2, MP2, and MNC within mutated BH10-LD4 virus when cultured in MT-2 cellsa
| Mutation | No. of clones with mutation during passage:
|
|||||
|---|---|---|---|---|---|---|
| 3 | 4 | 5 | 7 | 10 | 13 | |
| MA2 | 0 | 0 | 0 | 1 | 3 | 6 |
| MP2 | 2 | 5 | 6 | 6 | 6 | 6 |
| MNC | 0 | 1 | 6 | 6 | 6 | 6 |
| LD4 | 6 | 6 | 6 | 6 | 6 | 6 |
Six clones were sequenced per passage. Bold indicates the first appearance the given mutation.