Figure 11.

Delivery strategies and applications of fucoidan-based delivery carriers. (A) Schematic illustration of CFN-gel and its mode of action. (B) NIR fluorescence images of PBS-, free Ce6- or CFN-gel-treated mice. After 5 min and 24 h of intravenous injection of PBS (100 μL), free Ce6 (5 mg Ce6 kg⁻¹), or a CFN-gel (5 mg Ce6 equiv. kg⁻¹), NIR fluorescence images of the HT1080 tumor-bearing mice were obtained. (C) confocal fluorescence microscopic images of tumor sections prepared 24 h post-injection. Nuclei in the tumor sections were stained using DAPI. (D) Left: tumor growth curves of mice. Control group (n = 7), free Ce6 + PDT (n = 5), CFN-gel (n = 7) and CFN-gel + PDT (n = 5). PBS, free Ce6, or Ce6–fucoidan was injected intravenously on day 1. Light illumination (670 nm, 50 mW cm⁻², 20 J cm⁻²) of the tumors was conducted on day 2 for PDT. Right: representative photographs of the mice obtained on day 10. Adapted with permission from Cho MH, Li Y, Lo P-C, Lee H, Choi Y. Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer. Nano-Micro Lett. 2020;12(1):47. https://creativecommons.org/licenses/by-nc/4.0/).²⁷⁶