Figure 12.

Delivery strategies and applications of lignin-based delivery carriers (A) Schematic of the Synthesis Route of Au/lignin–tannin particles. (B) SEM and TEM images of Au/LT particles, and size distribution of Au particles. Used with permissions of Royal Society of Chemistry, from Synthesis of Au/lignin–tannin particles and their anticancer application, Jiang Z, Duan J, Guo X, Ma Y, Wang C, Shi B, 23, 18, 2021; permission conveyed through Copyright Clearance Center, Inc..³⁰⁷ (C) Schematic of the Synthesis Route of LG-M(N-DOX)-PEG Copolymer and illustration of the dual pH-responsive LG-M(N-DOX)-PEG NPs. (D)Digital photo of LG-M(N)-PEG solution after the release of lignin for different times at pH = 6.5. (E) In vitro release profiles of DOX from LG-M(N-DOX)-PEG NPs at different pH values (6.5 and 7.2). Adapted with permission from Yang Z, Zhou Z, Li Y, et al. Assessing the Potential of New Lignin-Based pH-Responsive Nanoparticles as Drug Carriers for Cancer Treatment. ACS Sustainable Chem. Eng. 2022;10(32):10590–10603. Copyright© 2022 American Chemical Society.³⁰⁸