Table 2.
Pharmacokinetic Parameters
| Parameters | Description |
|---|---|
| Cmax | Maximum observed concentration of a drug collected from an animal or human body |
| Cthrough | Means the lowest concentration from the initial moment of administration to the next administration when multiple administrations have reached steady state, and is a reflection of the level of accumulation of the drug |
| Tmax | Time to reach Tmax |
| AUC | Area under the concentration curve, representing the total drug exposure experienced by the subject in the study |
| T1/2 | Half-life, the time for the concentration of the drug to decrease by half |
| MRT | Mean residence time, the average time a drug molecule spends in the body |
| Vd (volume of distribution) | A volume estimated as the ratio of the blood concentration (C) to the amount of drug in the body (D) when the drug is absorbed and distributed to reach a steady state blood concentration. |
| CL (Clearance Rate) | The number of apparent volume of distribution of a drug removed from the body per unit of time, meaning how many volumes of plasma are cleared of the drug per unit of time |