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. 2024 Jun 24;86:101976. doi: 10.1016/j.molmet.2024.101976

Figure 5.

Figure 5

RNA sequencing analysis of tibialis anterior muscle in epithelial ovarian cancer (EOC) injected mice. Number of differentially expressed genes (DEGs) in each comparison were exemplified in a Venn diagram (A). Volcano plot showing -log10 p-value and log2 fold changes of DEGs for each comparison were also completed (B–D). Top 3 upregulated and top 3 downregulated biological processes enriched in DEGs at each time point were also analyzed and graphed (E–G) Top two upregulated and down regulated biological processes were also used to generate a chord plot with the corresponding DEGs and respective log fold changes at each time point (H–J). n = 6. C57BL/6J female mice ∼75 days post PBS injection as controls (CTRL); C57BL/6J female mice ∼45 days post ovarian cancer injection (45 Days); C57BL/6J female mice ∼75 days post ovarian cancer injection (75 Days); C57BL/6J female mice ∼90 days post ovarian cancer injection (90 Days).