Figure 8.

Summary of changes in a metastatic epithelial ovarian cancer cachexia model. When mice were injected with epithelial ovarian cancer, at a pre-metastasis time point (45 days post-injection) early muscle weakness was associated with decreases in pyruvate oxidation in both the tibialis anterior and diaphragm muscles. At this time, the tibialis anterior muscle did not exhibit muscle atrophy while the diaphragm did. With the exception of IL-6 in the diaphragm, there were no increases in TNF-$\alpha$ and atrophy markers of cancer cachexia at this time. During severe metastasis (90 days post-injection) both muscles exhibited muscle atrophy and muscle weakness, however the tibialis anterior recovered specific force production. Moreover, both muscles exhibited compensatory increases in submaximal pyruvate oxidation. Last, with the exception of IL-6 there were still no increases in TNF-$\alpha$ and atrophy markers of cancer cachexia.