RA	Rheumatoid arthritis
NSAIDS	Nonsteroidal anti-inflammatory medications
ETD	Etodolac
COX	Cyclo-oxygenase
NPs	Polymeric nanoparticle drug delivery system
SC	Stratum corneum
MN	Microneedle
CFAs	Complete Freund’s adjuvants
PVA	Polyvinyl alcohol
EE	Entrapment efficiency
PS	Particle size
PDI	Polydispersity index
ZP	Zeta potential
DL	Loading capacity
TEM	Transmission electron microscopy
PBS	Phosphate-buffered saline
TNF-α	Tumor necrosis factor alpha
IL-6	Interleukin 6
IL-1 β	Interleukin 1-beta.