FIG. 4.

Chimpanzee PBMC-mediated HIV-1 Gag peptide-specific cytotoxicity is genetically restricted. PBMC from chimpanzees 420, 424, and 487 were stimulated with peptides 8, 17, and 5, respectively. Effector cells from each of the chimpanzees were assessed for cytotoxicity by using as targets peptide-pulsed autologous B-LCL as well as B-LCL generated from PBMC of two other chimpanzees. Similarly, PBMC from chimpanzee C-1196 were stimulated with peptides 8, 9, and 20 to generate the effector cells. Autologous and allogeneic B-LCL were pulsed with peptides 8 (white bars), 9 (hatched bars), and 20 (black bars) and used as target cells.