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. 2024 Jul 19;17(7):962. doi: 10.3390/ph17070962
ABSs Asexual blood stages
Ac-COA Acetyl coenzyme A
ACS Acyl-CoA synthetase
AMS Adenosine-5′-sulfamate
aaRSs Aminoacyl-tRNA synthetases
ATP Adenosine triphosphate
BCKDH Branched-chain keto-dehydrogenase
CETSA Cellular thermal shift assay
CYP Cytochrome P450
DGFA Dual gamete formation assay
DMSO Dimethyl sulfoxide
DNMT DNA methyltransferase
EC50 50% effective concentration
ED90 90% effective dose
EIA Exflagellation inhibition assay
EM Electron microscopy
ETC Electron transport chain
FGAA Female gamete activation assay
G6PD Glucose-6-phosphate dehydrogenase
GAPDH Glyceraldehyde-3-phosphate dehydrogenase
GFP Green fluorescent protein
GST Glutathione S-transferase
HDAC Histone deacetylase
HEA Hydroxyethylamine
HMT Histone methyltransferase
IAP Inhibitor of apoptosis
IC50 50% inhibitory concentration
IF Immunofluorescence
iPanAms Inverted pantothenamides
JmjC Jumonji C
KDM Lysine demethylase
LDH Lactate dehydrogenase
MMV Medicines for Malaria Venture
ODA Ookinete development assay
PABP1 Polyadenylate-binding protein 1 complex
PCNA1 Proliferating cell nuclear antigen
PfCLK3 P. falciparum cyclin-dependent-like kinase
PfDHFR P. falciparum dihydrofolate reductase
PfATP4 P. falciparum Na+-efflux ATPase ATP4
PfPANK1 P. falciparum pantothenate kinase 1
PfPI4Kβ P. falciparum phosphatidylinositol 4-kinase type III β
PfeEF2 P. falciparum translation elongation factor 2
PfYRS P. falciparum tyrosine-tRNA synthetase
PfvapA P. falciparum V-type H + -ATPase
Pf20S P. falciparum 20S proteasome
PheRS Phenylalanyl-tRNA synthetase
PK Pharmacokinetics
PM Plasmepsins
PMIX Plasmepsin IX
PMX Plasmepsin X
PVM Parasitophorous vacuole membrane
RBCs Red blood cells
SAHA Suberoylanilide hydroxamic acid
SaLSSA Saponin-lysis sexual stage assay
SAR Structure–activity relationship
SMFA Standard membrane feeding assay
SPR Surface plasmon resonance
TAP Triaminopyrimidine
YRS Tyrosine-tRNA synthetase
WHO World Health Organization