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. 2024 Jul 21;16(14):2366. doi: 10.3390/nu16142366

Table 2.

Selected drugs and their impact on the microbiome [7,50].

Drug Effects on the Microbiome in Relation to the Pathogenesis of Alzheimer’s Disease
Combination of ampicillin, vancomycin, neomycin, metronidazole, amphotericin-B Decrease in Firmicutes and Bacteroidetes (and changes in bacterial metabolites).
Vancomycin Significantly altered gut microbiota composition (in neonatal vancomycin)
Streptozotocin and ampicillin Disruption in the equilibrium of gut flora
Penicillin V Altered gut microbiota composition
Antidepressant selective-serotonin reuptake inhibitors (SSRIs), sertraline, paroxetine and fluoxetine Antimicrobial activity against Gram-positive bacteria (such as Staphylococcus and Enterococcus)
SSRIs (fluoxetine) Induced depletion of cecal levels of Prevotella and Succinivibrio/reduction in Lactobacillus johnsonii and Bacteroidales
Tricyclic antidepressants (TCAs) Prevention of the growth of gut pathogens, such as E. coli, Yersinia enterocolitica.