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. 2024 Jul 15;16(7):943. doi: 10.3390/pharmaceutics16070943

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Expression profile of RSPO-LGR-RNF43/ZNRF in NBs and analysis of LGR5 expression in cell lines. (A) TCGA’s RNA-seq data of RSPO1/2/4, LGR4/5/6, and RNF43/ZNRF3 in the NB Target cohort. (B) Kaplan–Meier analysis of LGR5 expression vs. survival in the TCGA Target cohort. (C) Western blot result of LGR5 in three NB cells lines and their LGR5-knockout derivatives. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is loading control. (D) Internalization of 8F2 bound to LGR5 by confocal microscopy. Green vesicles represent internalized LGR5. Blue = nuclei.