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Generation of anti-LGR5 ADC and its binding to LGR5-expressing cells. (A) diagram of LGR5 antibody 8F2 or control antibody R20 conjugated with PEG4-azido-DBCO-PEG8-VA-PAB-SG3199. (B) Mass spectra of 8F2-SG3199 and R20-SG3199. (C) Saturation binding analysis of 8F2-SG3199 and R20-SG3199 on HEK293T cells stably expressing LGR5. Kd values were then calculated using GraphPad Prism 8 software. All assays were performed in triplicate.
