Table 2.
Biological and cancer cell line effects of various Cyclamen species. (↑: increases, ↓: decreases).
| Cyclamen Species | Plant Part | Biological Pathway Effect | Cancer Cell Line Effect | Reference |
|---|---|---|---|---|
| C. alpinum Dammann ex. spreng | Tubers | ↑ toxic LC50 in T. tubifex | ↓ cytotoxicity in HCT 116 and HT29 | [60,96] |
| C. coum Mill | Multiple parts | ↓ antibacterial activity | ↑ cytotoxicity HeLa and NSCLC H1299 | [82,97] |
| C. hederifolium Aiton | Tubers | ↓ cytotoxic activity | ↓ apoptosis in Hela, H-446, HT-29, U937 | [98] |
| C. persicum Mill | Tubers | ↑ cytotoxic activity | ↑ apoptosis in human carcinoma nasopharynx | [99] |
| C. pseudibericum Hildebr. | Tubers | ↓ cytotoxic activity | ↑ cytotoxicity on A549 cells ↓ number of A549 cells |
[79] |