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. 2024 Jul 1;17(7):857. doi: 10.3390/ph17070857

Figure 1.

Figure 1

Concentration−dependent curves of pinacidil effects on the human internal mammary artery in the presence of blocker glibenclamide. The relaxant effect of pinacidil on the contraction provoked by the 5-hydroxytriptamine on the segments of the human internal mammary artery (HIMA) in type-2 diabetes mellitus (T2DM) patients in the presence of three different concentrations (3, 10 and 30 µM) of the selective blocker of KATP channels, glibenclamide (GLB). The points (circles, triangles, squares and diamonds) are the means and the vertical lines show the SEM (n = 10–14 for the controls and n = 5–7 in the presence of GLB; n—number of segments); * p < 0.05; ** p < 0.01.