Figure 2.

The original recordings of the pinacidil effects on the human internal mammary artery (HIMA) in T2DM patients. The effect of pinacidil (closed square, 0.01–100 µM) on the HIMA segments precontracted with 5-hydroxytryptamine (5-HT, 100 µM) in the absence (A) and in the presence (B) of glibenclamide (Glb, 3 mM). The presence of the endothelium was tested by adding acetylcholine (Ach, 100 µM); papaverine (Pap, 100 µM) was added as a general vasodilator; W—wash.