Table 1.

Targets corresponding to inflammatory pathways.

Pathway	Target	FDR Values
IL-17 signaling pathway	LCN2, GSK3B, IL6, NF-κB1, TNF, PTGS2, CASP3, HSP90AA1, MAKP1, IKBKB, MAPK3, MAPK14, NF-κBIA, RELA	7.20 × 10−15
C-type lectin receptor signaling pathway	NF-κB1, IKBKB, NF-κBIA, RELA, PTGS2, PPP3CA, MAPK14, MAPK3, MAPK1, TNF, IL6, IL10, NF-κB2, CLEC4E	1.61 × 10−14
AGE-RAGE signaling pathway in diabetic complications	ICAM1, NOS3, F3, TNF, IL6, NF-κB1, SERPINE1, MAPK3, CASP3, RELA, MAPK1, CCND1, MAPK14	2.09 × 10−13
Human T-cell leukemia virus 1 infection	CDK2, RB1, CCND1, CDKN1A, MAPK3, PPP3CA, TP53, NFKBIA, NF-κB1, TNF, MAPK1, RELA, IL6, IKBKB, NF-κB2, ICAM1	4.24 × 10−13
NF-kappa B signaling pathway	PLAU, ICAM1, PTGS2, RELA, TNF, NF-κB1, NF-κB2, IKBKB, TLR4, NF-κBIA, LY96, BTK	5.96 × 10−12
HIF-1 signaling pathway	NOS2, NOS3, NF-κB1, INS, CDKN1A, SERPINE1, HMOX1, TLR4, MAPK3, MAPK1, RELA, IL6	6.31 × 10−12
TNF signaling pathway	TNF, IL6, RELA, NF-κB1, CASP3, IKBKB, PTGS2, MAPK1, MAPK3, ICAM1, MAPK14, NF-κBIA	1.51 × 10−11
Toll-like receptor signaling pathway	TNF, NF-κB1, LY96, TLR4, RELA, MAPK1, MAPK3, MAPK14, IL6, IKBKB, NF-κBIA	9.63 × 10−11
T cell receptor signaling pathway	IL10, IKBKB, TNF, NF-κB1, NF-κBIA, GSK3B, MAPK14, RELA, MAPK1, MAPK3, PPP3CA	9.63 × 10−11