TABLE 1.

Development of MAIDS in STAT6 knockout mice^a

STAT6 genotypeb	Wks after infection	Tissue wt (mg)		Histopathologyd
		Spleenc	Lymph nodesc
+/+	0	90	<10	N
	6	257	90	1
	10	525	223	2
+/−	0	100	<10	N
	6	325	168	1
	10	428	258	1–2
−/−	0	90	<10	N
	6	215	105	1
	10	662	474	2

^aData are for three mice per data point and are representative of three experiments involving two to three mice compared at each time point. 

^bMice of the indicated STAT6 genotypes were infected with LP-BM5 virus mixture and killed at the indicated time points. 

^cSpleens and lymph nodes were weighed and material was saved for histopathology. 

^dHistopathologic diagnoses were as follows: N, normal; 1, definitive evidence of MAIDS with germinal center expansion and proliferation of immunoblasts and plasmacytoid cells; 2, more advanced MAIDS with fusions of germinal centers, early loss of lymphoid architecture, and further expansions of blast cells.