Table 3.

Comparative pharmacokinetic parameters of TDF and reference TD-TAB (Cialis^®) in healthy human volunteers under fasting and fed states.

Condition	Items	Variable
		Cmax (ng/mL)	T/R, 90% CI	AUCt (h*ng/mL)	T/R, 90% CI	Tmax (h)
Fasting (n = 37)	TD-TAB	268.2 ± 77.7	0.936–1.105	6399.8 ± 2447.9	1.012–1.153	2.6 ± 1.7
	TDF-1	276.3 ± 83.9		6871.8 ± 2234.5		3.2 ± 2.2
Fed I (n = 10)	TD-TAB	416.4 ± 81.0	0.610–0.798	6562.4 ± 1269.4	0.884–1.022	2.3 ± 1.0
	TDF-1	290.4 ± 81.0		6237.3 ± 1548.0		7.9 ± 3.2
Fed II (n = 12)	TD-TAB	326.8 ± 77.4	0.735–0.972	6549.6 ± 3034.0	0.894–1.137	2.6 ± 2.6
	TDF-2	276.2 ± 100.3		6602.3 ± 3028.6		5.7 ± 6.1
Fed III (n = 10)	TD-TAB	408.6 ± 153.6	0.635–0.847	7097.6 ± 2631.7	0.929–1.074	3.2 ± 1.5
	TDF-1	299.6 ± 102.3		7089.9 ± 2525.1		6.8 ± 3.2
Fed IV (n = 8)	TD-TAB	400.8 ± 61.2	0.851–0.998	6354.9 ± 1542.9	0.958–1.045	2.4 ± 2.1
	TDF-1	367.3 ± 59.2		6382.5 ± 1501.7		4.8 ± 1.7