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. 2024 Jun 22;12(7):451. doi: 10.3390/toxics12070451

Table 1.

General information and safety-level data of incorporated cosmetic ingredients according to the CIR, CosIng, and/or COSMILE databases.

INCI Name CAS Nr. Description Cosmetic
Restriction
Maximum Conc. in Ready for Use Preparation Function(s) SCCS Opinions Ingredient Status Database (CosIng */CIR **/COSMILE ***) Reference
Aqua 7732-18-5 Water N N Solvent NA CosIng/COSMILE NA
Butylene Glycol Cocoate 73138-39-3 Coconut oil fatty acids, 2-hydroxybutyl ester N N Surfactant—emulsifying
Emulsion stabilizing
NA CosIng/CIR/COSMILE [25]
Glycerin 56-81-5 Glycerol N N Denaturant
Hair conditioning
NA CosIng/CIR/COSMILE [26]
Phenoxyethanol 122-99-6 2-Phenoxyethanol Annex V of the EU Cosmetics Regulation (1223/2009/EU) 1% Antimicrobial
Preservative
Opinion concerning restrictions on materials listed in annex VI of Directive 76/768/EEC on Cosmetic Products ****
Opinion on phenoxyethanol
CosIng/CIR/COSMILE [27,28,29]
Ethylhexylglycerin 70445-33-9 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol N N Deodorant
Skin conditioning
NA CosIng/CIR/COSMILE [30]
Hydrolysed Hyaluronic Acid Hydrolyzed hyaluronic acid is the hydrolysate of hyaluronic acid derived by an acid, enzyme or another method of hydrolysis N N Hair conditioning
Humectant
NA CosIng/CIR/COSMILE [31]
Fructose 57-48-7 / N N Humectant NA CosIng/CIR/COSMILE [32]
Aesculus hippocastanum (Horse chestnut) Extract 8053-39-2 Aesculus hippocastanum flower extract is the extract of the flowers of Horse chestnut, Aesculus hippocastanum L., Hippocastanaceae N N Skin conditioning NA CosIng/COSMILE NA

* CosIng—Cosmetic Ingredient Database, ** CIR—Cosmetic Ingredient Review, *** COSMILE Europe—Cosmetics Europe database; SCCS—Scientific Committee on Consumer Safety; **** the previous Directive 76/768/EC (adopted on 27 July 1976) was replaced by the EU Cosmetics Regulation (1223/2009/EU), adopted in 2009 and fully in force since July 2013; N—not applicable; NA—not available.