Table 5.
Hazard and exposure specifications of the cosmetic ingredients incorporated into the anti-ageing eye serum.
| Ingredient ID | CAS | INCI | Conc. % (w/w) | Annex | Mutagenicity | Skin Sensitization |
Dermal Abs. | MoS | TTC * |
|---|---|---|---|---|---|---|---|---|---|
| Deionized Water | 7732-18-5 | Aqua | 92.55 | - | - | - | - | - | - |
| Cocoate BG | 73138-39-3 | Butylene Glycol Cocoate | 1.00 | - | - | - | - | - | - |
| Glycerin | 56-81-5 | Glycerin | 4.00 | - | NON-Mutagen | NON-Sensitizer | 80% | 334.07 | 0.046 mg/kg bw/day |
| Phenoxyethanol | 122-99-6 | Phenoxyethanol | 0.90 | V | NON-Mutagen | NON-Sensitizer | 80% | 460.28 | 0.046 mg/kg bw/day |
| Ethylhexylglycerin | 70445-33-9 | Ethylhexylglycerin | 0.10 | - | NON-Mutagen | NON-Sensitizer | 80% | 9737.47 | 0.0023 mg/kg bw/day |
| Hydrolyzed Hyaluronic Acid | 9004-61-9 | Hydrolyzed Hyaluronic Acid | 0.70 | - | NON-Mutagen | Sensitizer | 10% | 9,713,408.1 | 0.0023 mg/kg bw/day |
| Fructose | 57-48-7 | Fructose | 2.50 | - | NON-Mutagen | NON-Sensitizer | 80% | 2120.28 | 0.046 mg/kg bw/day |
| Aesculus hippocastanum (Horse Chestnut) Extract | 8053-39-2 | Aesculus hippocastanum (Horse Chestnut) Extract | 0.50 | - | - | - | - | - | - |
| experimental value | good reliability | moderate reliability | low reliability NON-Senzitizer |
low reliability Senzitizer |
Product type: anti-ageing eye serum. *—TTC values according to Cramer class classification and adapted for cosmetic ingredients, as calculated by SpheraCosmolife: Class I—low toxicity (0.046 mg/kgbw/d) and Class II—medium toxicity (0.023 mg/kgbw/d).