Figure 5.

In vitro characterization of STR YF-ZIK batches produced in selected host cells. Plaque morphology of YF-ZIK batches vs. parental YF17D virus. BHK-21J cells in 6-well plates infected and plaques visualized 6 days post infection. (a) Plaque phenotypes of different YF-ZIK batches and YF17D are shown. (b) Size distribution of plaques. Median ± IQR for 100–150 individual plaques for each batch. Error bars represent the lowest and highest values. Kruskal–Wallis test followed by Dunn’s multiple comparison test, **** p < 0.0001.