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. 2024 Jul 9;12(7):755. doi: 10.3390/vaccines12070755

Figure 6.

Figure 6

In vivo characterization of neurovirulence of STR YF-ZIK batches from different cell lines. Comparative analysis of BALB/c pups following i.c. inoculation of 10 (a) or 1000 PFU (b) of YF-ZIK derived from pIX (blue circles), HEKDyn (brown diamonds), and Veroadh cells (gray squares), or 10 PFU of YF17D (red triangles) or sham (hollow circles). (a) Weight evolution of 3–6-day-old pups after i.c. with 10 PFU of YF-ZIK grown on Veroadh (original seed virus; n = 9), HEKDyn (n = 11), or pIX cells (n = 10), 10 PFU of YF17D (positive control; n = 5) or sham. (b) Item using 1000 PFU of YF-ZIK. (c) Area under the curve (AUC) mean ± SEM. Kruskal–Wallis test followed by Dunn’s multiple comparison to assess the statistical significance with * p < 0.05 and ** p < 0.01 and (d) Survival rate (number of surviving mice at the endpoint is indicated).