Table 1.
Longitudinal Associations Between Reaction Score and HAI GMT.
| Reaction Type | Antigen | Study Group | Unadjusted GMR * (95% CI) |
p-Value | Adjusted GMR *^ (95% CI) |
p-Value |
|---|---|---|---|---|---|---|
| Global | H1N1 | IM | 1.07 (0.53, 2.16) |
0.85 | 0.98 (0.58, 1.66) |
0.95 |
| MNP | 0.87 (0.50, 1.52) |
0.62 | 0.85 (0.58, 1.24) |
0.38 | ||
| H3N2 | IM | 0.83 (0.47, 1.49) |
0.54 | 0.74 (0.45, 1.22) |
0.23 | |
| MNP | 0.81 (0.50, 1.29) |
0.37 | 0.78 (0.54, 1.12) |
0.17 | ||
| B | IM | 1.21 (0.80, 1.83) |
0.36 | 0.95 (0.63, 1.42) |
0.79 | |
| MNP | 0.80 (0.53, 1.22) |
0.30 | 0.81 (0.58, 1.14) |
0.22 | ||
| Systemic | H1N1 | IM | 0.73 (0.35, 1.52) |
0.40 | 0.65 (0.38, 1.12) |
0.12 |
| MNP | 0.91 (0.36, 2.27) |
0.83 | 0.85 (0.45, 1.60) |
0.61 | ||
| H3N2 | IM | 0.64 (0.35, 1.18) |
0.15 |
0.54
(0.33, 0.89) |
0.02 | |
| MNP | 1.43 (0.66, 3.10) |
0.36 | 1.42 (0.77, 2.60) |
0.26 | ||
| B | IM | 1.07 (0.69, 1.65) |
0.77 | 0.81 (0.53, 1.24) |
0.33 | |
| MNP | 0.84 (0.42, 1.66) |
0.61 | 0.78 (0.45, 1.36) |
0.38 | ||
| Local | H1N1 | IM | 0.59 (0.22, 1.54) |
0.27 | 0.6 (0.30, 1.21) |
0.15 |
| MNP | 1.53 (0.90, 2.61) |
0.12 |
1.54
(1.05, 2.25) |
0.03 | ||
| H3N2 | IM | 0.46 (0.21, 1.01) |
0.05 |
0.37
(0.19, 0.72) |
<0.01 | |
| MNP | 0.72 (0.46, 1.13) |
0.15 |
0.63
(0.44, 0.90) |
0.01 | ||
| B | IM | 1.06 (0.60, 1.87) |
0.85 | 0.89 (0.51, 1.55) |
0.68 | |
| MNP | 0.97 (0.65, 1.45) |
0.89 | 1.00 (0.71, 1.41) |
0.99 |
HAI: hemagglutination inhibition; GMT: geometric mean titer; GMR: geometric mean titer ratio; CI: confidence interval; IM: intramuscular; MNP: microneedle patch. * Estimated geometric mean titer ratio for those in the higher score category compared with those in the lower score category. ^ Adjusted for body mass index category, sex, prior inactivated influenza vaccination, race, ethnicity, and study day. Bolded type indicates p-Value < 0.05.