Table 1.
Overview of parameters associated with disease severity in chemically restrained hamsters.
| Challenge | Hamster ID | Change in bpm on D7 | Absolute bpm on D7 | Observed Breathing on D7 |
Max. Body Weight Loss | Body Weight Change on D7 |
Absolute Body Weight on D7 | Lung Weight on D7 | Relative Lung Weight on D7 (to Body Weight on D0) | Lung Histopathology on D7 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Extent | Severity Sum Score | ||||||||||
| Prototype | B09 | +124.0% | 122 | Rapid + labored | −14.1% | −10.9% | 112.6 g | 1.40 g | 1.08% | 35% | 11 |
| B10 | +73.3% | 81 | - | −12.8% | −8.5% | 118.8 g | 1.31 g | 1.07% | 43% | 11 | |
| B06 | +62.4% | 69 | Rapid | −13.2% | −9.6% | 109.7 g | 1.26 g | 1.05% | 40% | 10 | |
| B08 | +14.4% | 52 | Rapid | −13.9% | −7.4% | 117.4 g | 1.11 g | 0.90% | 35% | 10 | |
| XBB.1.5 | A01 | +23.8% | 46 | - | −4.0% | +3.6 | 109.9 g | 0.79 g | 0.66% | 12% | 4 |
| A03 | +8.6% | 44 | - | −2.5% | +3.4 | 120.0 g | 0.90 g | 0.71% | 14% | 5 | |
| A02 | +4% | 45 | - | −7.8% | +1.4 | 116.4 g | 0.94 g | 0.78% | 30% | 8 | |
| A05 | −20% | 44 | - | −2.8% | +3.1 | 122.2 g | 0.79 g | 0.61% | 4% | 3 | |
Note: From both groups, one hamster was excluded from this list due to movement/insufficient sedation in the WBP chamber on D7.