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Schematic illustration of phosphodiesterases (PDEs) in smooth muscle cells. The cartoon highlights the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by PDEs in smooth muscle cells to control vessel constriction and proliferation. CaM, calmodulin; GPCR, G protein-coupled receptor; NO, nitric oxide; NP, natriuretic peptide; sGC, soluble guanylyl cyclase.
