Table 1.
KEGG different metabolic pathways ID and the proportion of different metabolic pathways between WT shock vs SDC-1 shock groups (VIP ≥ 1.0 and p < 0.05)
| Pathway | All metabolites with pathway annotation (455) | p value | Pathway ID | C_id desc |
|---|---|---|---|---|
| Histidine metabolism | 15 (3.3%) | 0.006071 | ko00340 | Carnosine; nalpha-(beta-alanyl)-L-histidine |
| N(pi)-methyl-L-histidine; N-pros-methyl-L-histidine; 3-methylhistidine; etc | ||||
| Beta-alanyl-N-methyl-L-histidine; anserine | ||||
| Imidazole-4-acetate; imidazoleacetic acid; 4-imidazoleacete | ||||
| Ergothionenine | ||||
| Vitamin digestion and absorption | 16 (3.52%) | 0.008773 | ko04977 | Nicotinamide; nicotinic acid amide; niacinamide; vitamin PP |
| Cholesterol; cholest-5-en-3beta-ol | ||||
| Pantothenate; pantothenic acid; (R)-pantothenate | ||||
| Carnosine; nalpha-(beta-alanyl)-L-histidine | ||||
| Beta-alanyl-N-methyl-L-histidine; anserine | ||||
| Thiamine; vitamin B1; aneurin; antiberiberi factor | ||||
| Beta-alanine metabolism | 10 (2.2%) | 0.026139 | ko00410 | Carnosine; Nalpha-(beta-alanyl)-L-histidine |
| Pantothenate; pantothenic acid; (R)-pantothenate | ||||
| beta-Alanyl-N-methyl-L-histidine; anserine | ||||
| Retrograde endocannabinoid signaling | 10 (2.2%) | 0.026139 | ko04723 | Phosphatidylcholine; lecithin; phosphatidyl-N-trimethylethanolamine; etc |
| 2-Arachidonoylglycero; 2-arachidonoyl-sn-glycerol; 2-AG | ||||
| Diacylglycerol; diglyceride | ||||
| Fat digestion and absorption | 6 (1.32%) | 0.028354 | ko04975 | Diacylglycerol; diglyceride |
| Cholesterol; cholest-5-en-3beta-ol | ||||
| Phosphatidate; phosphatidic acid; 1,2-diacyl-sn-glycerol-3-phosphate; 3-sn-phosphatidate | ||||
| Longevity-regulating pathway worm | 3 (0.66%) | 0.042605 | ko04212 | Nicotinamide; nicotinic acid amide; vitamin PP |
| Nicotinamide; nicotinic acid amide; vitamin PP |