Table 1.
Patient Characteristics
| Trait | Category | Placebo Pooled (n = 12) | AB002 1.5 µg/kg (n = 12) | AB002 3 µg/kg (n = 12) |
|---|---|---|---|---|
| Sex | Female | 3 (25%) | 4 (33%) | 3 (25%) |
| Male | 9 (75%) | 8 (67%) | 9 (75%) | |
| Race | Black or African American | 12 (100%) | 11 (92%) | 10 (83%) |
| White | 0 (0%) | 1 (8%) | 2 (17%) | |
| Ethnicity | Hispanic or Latino | 0 (0%) | 1 (8%) | 0 (0%) |
| Not Hispanic or Latino | 12 (100%) | 11 (92%) | 12 (100%) | |
| Age, mean (SD), y | 54.6 (12.30) | 54.8 (8.29) | 53.3 (9.56) | |
| Weight, mean (SD), kg | 80.2 (13.32) | 86.5 (16.77) | 92.3 (30.82) | |
| BMI, mean (SD) | 26.5 (3.62) | 28.2 (5.69) | 29.5 (9.33) | |
| Tobacco use, n (%) | 2 (17%) | 1 (8%) | 2 (17%) | |
| Diagnosis ESRD, mean (SD), y | 9.4 (7.89) | 6.5 (4.38) | 6.3 (4.73) | |
| Primary cause of kidney failure, n (%) | Hypertension | 5 (42%) | 7 (58%) | 4 (33%) |
| Diabetes | 3 (25%) | 2 (17%) | 4 (33%) | |
| Polycystic kidney disease | 0 (0%) | 1 (8%) | 0 (0%) | |
| Unknown | 1 (8%) | 0 (0%) | 0 (0%) | |
| Multiple | 3 (25%) | 2 (17%) | 4 (33%) | |
| aPTTa, mean (SD), s | 34.4 (4.33) | 35.0 (4.06) | 34.7 (3.63) | |
| Platelet counta, mean (SD), K/µL | 205.6b (76.39) | 175.1 (63.57) | 211.0 (57.35) | |
| Hemoglobina, mean (SD), g/dL | 11.8b (0.69) | 12.0 (1.58) | 11.8 (1.22) | |
| Blood pressurea, mean (SD), mmHg | Systolic | 138.0 (28.68) | 142.4 (20.51) | 134.1 (14.78) |
| Diastolic | 77.6 (15.41) | 84.3 (9.20) | 75.5 (9.21) | |
| Comorbidities, n (%) | Hypertension | 11 (92%) | 12 (100%) | 11 (92%) |
| Diabetes | 6 (50%) | 6 (50%) | 7 (58%) | |
| Cardiovascular diseasec | 2 (17%) | 7 (58%) | 3 (25%) | |
| History of extremity amputation | 4 (33%) | 2 (17%) | 3 (25%) | |
| Cancer | 1 (8%) | 0 (0%) | 0 (0%) |
y years, kg kilogram, s seconds, K/µL = 103/microliter, g/dL grams/deciliter, mmHg millimeters mercury.
aValue at screening.
bn = 11 patients.
cIncludes cardiac bypass, cardiac stent, cerebral aneurysm, congestive heart failure, coronary artery disease, myocardial infarction, stroke, and transient ischemic attack.