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. 2024 Jul 26;14:16391. doi: 10.1038/s41598-024-65949-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemistry and double immunofluorescence using 2D6-2C6 antibody on autopsied AD cases. (A–F) Immunohistochemistry using 2D6-2C6 antibody on autopsied AD cases. The panels (A–C) display CA1 of autopsied samples. Two cases with AD (A, B) demonstrated 2D6-2C6-immunopositivity in the CA1, whereas a neurologically healthy control (C) did not show dense aggregates. The 2D6-2C6 antibody immunolabeled NFTs (D), pretangles (E), and neuritic plaque (F) in the CA1. Black scale bars = 100 μm (A–C) and 20 μm (D–F). (G–L) Double immunofluorescence using 2D6-2C6 antibody combined with other anti-tau antibodies. All panels here are taken at the CA1 from the same AD case. Panels (G–I) indicate a combination of 2D6-2C6 and AT8, whereas panels (J–L) indicate a combination of 2D6-2C6 and T22. The 2D6-2C6 fluorescent signals were mostly merged with AT8 signals for NFT (G), pretangle (H), and neuritic plaque (I). The 2D6-2C6 and T22 antibodies also exhibited colocalization (J–L). Pretangle (K) was more sensitively detected by 2D6-2C6 antibody compared to T22. White scale bars = 10 μm.