Table 1.

Primary and secondary outcomes.

Primary outcome

Occurrence of moderate or severe AKI (KDIGO stage 2 or 3) within 72 h after surgery

Secondary outcomes

1.Adherence to the KDIGO bundle5 2.Occurrence and severity of any stage of acute kidney injury within 3 days after surgery 3.Change in biomarker values during 12 h after initial measurement of [TIMP2]∗[IGFBP7] 4.Free-days of mechanical organ support through to day 3 5.Free-days of vasopressors through day 3 6.Need of RRT at day 30 and 90 7.Duration of RRT at day 30 and 90 8.Renal recovery at day 90 9.30-day and 90-day mortality 10.ICU length-of-stay and Hospital length-of-stay 11.Major adverse kidney events (MAKE90) (defined as the composite of death, use of RRT and persistent renal dysfunction (defined as serum creatinine ≥2x to baseline value at hospital discharge)) at day 90