Table 3.
Mixed effects hierarchical multivariable logistic regression for in-hospital mortality adjusted for sex, illness severity, COVID-19 status, frailty, ICU activity index and hospital type (with site as random effect) in all patients and in subgroups categorised by a. invasive therapies (invasive ventilation, renal replacement or ECMO), b. no invasive therapies and c. patients in public hospital ICUs.
| Patient category | CCRN group | No. of patients | Observed mortality | Adjusted Odds Ratio (95% CI) | p value |
|---|---|---|---|---|---|
| All patients | CCRN >75% | (n = 6563) | 534 (8.1%) | Reference value | |
| CCRN 50–75% | (n = 7695) | 859 (11.2%) | 1.21 (1.02–1.45) | 0.032 | |
| CCRN <50% | (n = 2360) | 252 (10.7%) | 1.21 (0.94–1.55) | 0.14 | |
| Subgroups | |||||
| a. Invasive ventilation, renal replacement or ECMO | CCRN >75% | (n = 2751) | 352 (12.8%) | Reference value | |
| CCRN 50–75% | (n = 3297) | 602 (18.3%) | 1.35 (1.11–1.64) | 0.003 | |
| CCRN <50% | (n = 952) | 169 (17.8%) | 1.28 (0.98–1.66) | 0.07 | |
| b. No invasive ventilation, renal replacement or ECMO | CCRN >75% | (n = 3812) | 182 (4.8%) | Reference value | |
| CCRN 50–75% | (n = 4398) | 257 (5.8%) | 1.05 (0.79–1.39) | 0.76 | |
| CCRN <50% | (n = 1408) | 83 (5.9%) | 1.14 (0.76–1.71) | 0.52 | |
| c. Public hospital ICUs | CCRN >75% | (n = 4177) | 425 (10.2%) | Reference value | |
| CCRN 50–75% | (n = 7274) | 844 (11.6%) | 1.27 (1.06–1.52) | 0.011 | |
| CCRN <50% | (n = 2350) | 251 (10.7%) | 1.24 (0.97–1.59) | 0.08 | |
For full multivariable models see Appendix Table 5. CCRN, Critical Care Registered Nurse; CI, Confidence interval; ECMO, Extracorporeal membrane oxygenation; ICU, Intensive Care Unit.