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. 2024 Jul 26;29:387. doi: 10.1186/s40001-024-01930-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — BA regulated DDP sensitivity through the KEAP1-NRF2/HO-1 pathway. A The relative levels of KEAP1, NRF2, and HO-1 in A549 and A549/DDP cells were examined by qRT-PCR; B Western blot was utilized to measure the protein abundance of KEAP1, NRF2, and HO-1; C IF assay was applied to analyze the activities of HO-1, scale bar = 25 μm; D The level of LC3 was assessed by IF, scale bar = 25 μm; E Western blot was used to measure the expression of LC3 II and I; F Cell autophagy was observed on a TEM, scale bar = 500 nm. *P < 0.05 vs Control; #P < 0.05 vs DDP

Fig. 2 — BA regulated DDP sensitivity through the KEAP1-NRF2/HO-1 pathway. A The relative levels of KEAP1, NRF2, and HO-1 in A549 and A549/DDP cells were examined by qRT-PCR; B Western blot was utilized to measure the protein abundance of KEAP1, NRF2, and HO-1; C IF assay was applied to analyze the activities of HO-1, scale bar = 25 μm; D The level of LC3 was assessed by IF, scale bar = 25 μm; E Western blot was used to measure the expression of LC3 II and I; F Cell autophagy was observed on a TEM, scale bar = 500 nm. *P < 0.05 vs Control; #P < 0.05 vs DDP