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. 2024 Jul 26;29:387. doi: 10.1186/s40001-024-01930-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The KEAP1-NRF2/HO-1 pathway was involved in BA-mediated sensitivity of NSCLC to DDP in vivo. A Mouse growth curve in different groups; B Tumor volume was estimated twice a week; C Tumors were weighed on the 28th day; D The expression of KEAP1 was determined by qRT-PCR and western blot; E The abundance of NRF2, HO-1, and LC3 was detected by western blot; F Flow cytometry was applied to measure the ratio of M1 macrophages (F4/80⁺ and CD11c⁺). G The protein levels of SLC7A11, GPX4, SLC40A1, and transferrin were determined by western blot; H GSH and GSSH levels were determined. *P < 0.05 vs Control; #P < 0.05 vs BA + DDP; &P < 0.05 vs DDP + DTX

Fig. 6 — The KEAP1-NRF2/HO-1 pathway was involved in BA-mediated sensitivity of NSCLC to DDP in vivo. A Mouse growth curve in different groups; B Tumor volume was estimated twice a week; C Tumors were weighed on the 28th day; D The expression of KEAP1 was determined by qRT-PCR and western blot; E The abundance of NRF2, HO-1, and LC3 was detected by western blot; F Flow cytometry was applied to measure the ratio of M1 macrophages (F4/80⁺ and CD11c⁺). G The protein levels of SLC7A11, GPX4, SLC40A1, and transferrin were determined by western blot; H GSH and GSSH levels were determined. *P < 0.05 vs Control; #P < 0.05 vs BA + DDP; &P < 0.05 vs DDP + DTX