Fig. 4.

A) Sagittal plane at 4 weeks and typical pictures of micro-CT of femurs of rats with bone defects at 4 and 8 weeks (scale bar: 1 mm, yellow circles represented the initial position of bone defect). B) Morphological parameters of the bone mineral density (BMD), bone volume/tissue volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th). (DM: diabetes mellitus, AB: autologous bone, MetS: Metformin scaffolds; n = 6 per group, data are provided as means ± SD, *p < 0.05, **p < 0.01). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)