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Therapeutic mechanism of LRsAR nanomedicine. In neuronal cells, the endosome escape of siBACE1 or siGSK3β in LRsAR nanomedicine can downregulate the expression of BACE1 or GSK3β, reduce the production of Aβ or the hyperphosphorylation of Tau, while releasing rutin to rescue mitochondrial function and decrease ROS. Created with BioRender.com.
