Table 2.
Associations Between Childhood Adversity, Mediators of Interest, and Incident Psychotic Experiences
| Predictor | Outcome | Unadjusted | Adjusted* | ||
|---|---|---|---|---|---|
| OR (95% CI) | P Values | OR (95% CI) | P Values | ||
| Cumulative childhood adversity | Incident psychotic experiences | 1.41 (1.28–1.56) | <.001 | 1.34 (1.21–1.49) | <.001 |
| Mediators of interest | |||||
| Anxiety | 2.51 (1.89–3.32) | <.001 | 2.27 (1.68–3.08) | <.001 | |
| Depression | 2.03 (1.46–2.83) | <.001 | 1.69 (1.18–2.42) | .004 | |
| External locus of control | 1.18 (1.11–1.25) | <.001 | 1.14 (1.07–1.21) | <.001 | |
| Negative symptoms | 1.06 (1.04–1.08) | <.001 | 1.05 (1.02–1.07) | <.001 | |
| Cumulative childhood adversity | Anxiety | 1.41 (1.30–1.54) | <.001 | 1.38 (1.26–1.51) | <.001 |
| Depression | 1.35 (1.23–1.49) | <.001 | 1.31 (1.18–1.45) | <.001 | |
| Outcome | B (95% CI) | P Values | B (95% CI) | P Values | |
|---|---|---|---|---|---|
| External locus of control | 0.30 (0.23–0.37) | <.001 | 0.26 (0.19–0.33) | <.001 | |
| Negative symptoms | 0.85 (0.67–1.02) | <.001 | 0.79 (0.62–0.97) | <.001 |
Note: Analyses between mediators of interest and incident psychotic experiences additionally adjusted for childhood adversity and cannabis use at 14 years. N = 5136 (estimates pooled based on 50 imputed datasets).
95% CI, 95% confidence interval.
*Analyses adjusted for: sex, ethnicity, highest maternal education, maternal occupation, paternal occupation, and parental history of psychopathology.