Table 3.

Total, Direct, and Indirect Effect for Childhood Adversity and Incident Psychotic Experiences

	Unadjusted Model	Model 1	Model 2
	OR (95% CI)	OR (95% CI)	OR (95% CI)
Total causal effect	1.40 (1.28–1.53)	1.32 (1.20–1.46)	1.31 (1.19–1.45)
Natural direct effect	1.30 (1.19–1.43)	1.24 (1.12–1.37)	1.24 (1.12–1.37)
Natural indirect effect	1.07 (1.05–1.10)	1.07 (1.04–1.09)	1.06 (1.03–1.08)
Proportion mediated	21.1%	22.6%	19.9%

Note: Using 100 bootstrap samples, and normal-based confidence intervals (CI). Mediators examined: anxiety, depression, external LoC, and negative symptoms. N = 5136. Model 1 adjusted for: sex, ethnicity, highest maternal education, maternal occupation, paternal occupation, and parental history of psychopathology. Model 2: Model 1 + additionally accounting for cannabis use (intermediate confounder).