Table 1.
MEGA sample demographics
| T1 | DTI | Multimodal | |||||||
|---|---|---|---|---|---|---|---|---|---|
| C | SZ | Psychosis | C | SZ | Psychosis | C | SZ | Psychosis | |
| N | 315 | 309 | 618 | 229 | 224 | 441 | 209 | 192 | 385 |
| Sex, M, n (%) | 158 (50%) | 216 (69%) | 353 (57%) | 122 (53%) | 161 (72%) | 263 (60%) | 114 (55%) | 136 (70%) | 227 (59%) |
| Age, yrs. (SD) | 36.8 (12.6) | 36.2 (13.0) | 37.1 (12.8) | 38 (13.0) | 37.2 (12.8) | 37.8 (12.6) | 37.3 (12.8) | 36.9 (12.7) | 37.5 (12.5) |
| Race, n (%) | |||||||||
| Caucasian | 159 (50%) | 145 (47%) | 281 (45%) | 101 (44%) | 103 (46%) | 185 (42%) | 89 (43%) | 87 (45%) | 125 (32%) |
| African American | 145 (46%) | 147 (48%) | 307 (50%) | 124 (54%) | 108 (48%) | 236 (54%) | 116 (56%) | 94 (49%) | 209 (54%) |
| Other | 11 (3%) | 17 (6%) | 30 (5%) | 4 (2%) | 13 (6%) | 20 (5%) | 4 (2%) | 11 (6%) | 18 (5%) |
| IQ | 102.9 (14.8) | 94.6 (15.7) | 95.4 (15.3) | 101.8 (15.6) | 94.4 (15.5) | 94.1 (15.3) | 102.7 (15.4) | 94.4 (15.5) | 94.3 (15.4) |
| Diagnostic breakdown | |||||||||
| SZ | NA | 309 (100%) | 309 (50%) | NA | 224 (100%) | 224 (51%) | NA | 192 (100%) | 192 (50%) |
| SAD | NA | NA | 164 (27%) | NA | NA | 136 (31%) | NA | NA | 118 (31%) |
| BPD | NA | NA | 135 (22%) | NA | NA | 72 (16%) | NA | NA | 67 (17%) |
| OTH | NA | NA | 10 (2%) | NA | NA | 9 (2%) | NA | NA | 8 (2%) |
| a Symptoms, Mean (SD) | NA | N: 15.8 (5.6) P: 15.8 (5.5) |
N: 14.4 (5.2) P: 15.4 (5.5) |
NA | N: 15.0 (5.6) P:15.2 (5.6) |
N: 14.5 (5.4) P:15.1 (5.6) |
NA | N: 15.1 (5.7) P:15.2 (5.5) |
N: 14.3 (5.5) P:15.0 (5.5) |
| CPZ Equivalents, Mean (SD) | NA | 493.4 (506.2) | 386.3 (443.4) | NA | 553.2 (632.6) | 415.8 (523.2) | NA | 515.7 (547.6) | 381.8 (455.3) |
aSymptoms were assessed via the PANSS for BSNIP and COBRE; this was not available for the PSY-DIS study. As such, symptom means for the Mega sample are averaged over BSNIP and COBRE studies only. SZ, schizophrenia; SAD, schizoaffective disorder; BPD, bipolar disorder with psychosis; OTH, other psychotic disorder; N, negative PANSS subscale; P, positive PANSS subscale.