TABLE 1.
Genetic diversity in pro
| Mutation type | Average intrapatient distance, T (%)a
|
No. of variable sites | ||
|---|---|---|---|---|
| Individual variable siteb | Any variable sitec | Any sited | ||
| Synonymous | 29.5 | 4.7 | 0.49 | 31 |
| Nonsynonymous | 21.9 | 4.3 | 0.23 | 16 |
| Synonymous and nonsynonymous | 27.5 | 4.5 | 0.72 | 47 |
| Sporadic synonymouse | 0.05 | 16 | ||
| Sporadic nonsynonymouse | 0.07 | 23 | ||
| Sporadic synonymous and nonsynonymouse | 0.12 | 39 | ||
a
Intrapatient genetic distance in pro, T, averaged over one of three groups of bases in each infected individual and then averaged over individuals.
b
Bases which are variable in a given individual only.
c
Bases which are variable in any individual.
d
All bases in pro.
e
Substitutions present in a single copy per database and excluded from the first three rows as PCR error suspects. Note the difference in relative number of synonymous sites between sporadic and nonsporadic substitutions.