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. 2024 Jul 27;15:6343. doi: 10.1038/s41467-024-50673-7

Fig. 1. Role of PrimPol in replication gaps and olaparib sensitivity in ALC1-deficient BRCA1 mutant SUM149PT cells.

Fig. 1

a Immunoblot showing depletion of ALC1 and PrimPol. Representative of three blots. b Schematic of S1-nuclease fiber assay. IdU: 5-iodo-2’-deoxyuridine. c Analysis of IdU tract length in the indicated cell lines in the absence (left) and presence (right) of olaparib. Median values are indicated. P values derived by Kruskal–Wallis test from >300 fibers/sample collected over three biologically independent experiments. d Sensitivities of the indicated cell lines to olaparib. Data are mean ± s.e.m from three biologically independent experiments. Source data are provided as a Source data file.